病理系统地诱导形态学变化，从而提供了主要但不足以量化的可观察到诊断来源。该研究基于计算机断层扫描（CT）体积的形态特征（3D形态学）开发了病理状态的预测模型。开发了一个完整的工作流程，以进行网状提取和简化器官表面的工作流程，并与平均曲率和网状能的分布自动提取形态特征自动提取。然后对XGBoost监督分类器进行了训练和测试，以预测病理状态。该框架应用于肺结节恶性肿瘤的预测。在具有恶性肿瘤的NLST数据库的子集中，仅使用3D形态学证实了活检，将肺结节的分类模型分类为恶性与良性AUC的良性0.964。 （1）临床相关特征的其他三组经典特征经过训练和测试，AUC为0.58，（2）111辐射因子学的AUC为0.976，（3）含有结节大小，衰减和衰减和衰减的放射科医生地面真相（GT） Spiculation定性注释的AUC为0.979。我们还测试了Brock模型并获得0.826的AUC。将3D形态学和放射素学特征结合在一起，可以实现最新的结果，而AUC为0.978，其中3D形态学具有一些最高的预测能力。作为对公共独立队列的验证，将模型应用于LIDC数据集，3D形态学的AUC达到0.906，而3D型物体+放射线学则获得了0.958的AUC，在挑战中排名第二。它将曲率分布确定为预测肺结核恶性肿瘤的有效特征，并可以直接应用于任意计算机辅助诊断任务。

While the capabilities of autonomous systems have been steadily improving in recent years, these systems still struggle to rapidly explore previously unknown environments without the aid of GPS-assisted navigation. The DARPA Subterranean (SubT) Challenge aimed to fast track the development of autonomous exploration systems by evaluating their performance in real-world underground search-and-rescue scenarios. Subterranean environments present a plethora of challenges for robotic systems, such as limited communications, complex topology, visually-degraded sensing, and harsh terrain. The presented solution enables long-term autonomy with minimal human supervision by combining a powerful and independent single-agent autonomy stack, with higher level mission management operating over a flexible mesh network. The autonomy suite deployed on quadruped and wheeled robots was fully independent, freeing the human supervision to loosely supervise the mission and make high-impact strategic decisions. We also discuss lessons learned from fielding our system at the SubT Final Event, relating to vehicle versatility, system adaptability, and re-configurable communications.

The Government of Kerala had increased the frequency of supply of free food kits owing to the pandemic, however, these items were static and not indicative of the personal preferences of the consumers. This paper conducts a comparative analysis of various clustering techniques on a scaled-down version of a real-world dataset obtained through a conjoint analysis-based survey. Clustering carried out by centroid-based methods such as k means is analyzed and the results are plotted along with SVD, and finally, a conclusion is reached as to which among the two is better. Once the clusters have been formulated, commodities are also decided upon for each cluster. Also, clustering is further enhanced by reassignment, based on a specific cluster loss threshold. Thus, the most efficacious clustering technique for designing a food kit tailored to the needs of individuals is finally obtained.

Purpose: Tracking the 3D motion of the surgical tool and the patient anatomy is a fundamental requirement for computer-assisted skull-base surgery. The estimated motion can be used both for intra-operative guidance and for downstream skill analysis. Recovering such motion solely from surgical videos is desirable, as it is compliant with current clinical workflows and instrumentation. Methods: We present Tracker of Anatomy and Tool (TAToo). TAToo jointly tracks the rigid 3D motion of patient skull and surgical drill from stereo microscopic videos. TAToo estimates motion via an iterative optimization process in an end-to-end differentiable form. For robust tracking performance, TAToo adopts a probabilistic formulation and enforces geometric constraints on the object level. Results: We validate TAToo on both simulation data, where ground truth motion is available, as well as on anthropomorphic phantom data, where optical tracking provides a strong baseline. We report sub-millimeter and millimeter inter-frame tracking accuracy for skull and drill, respectively, with rotation errors below 1{\deg}. We further illustrate how TAToo may be used in a surgical navigation setting. Conclusion: We present TAToo, which simultaneously tracks the surgical tool and the patient anatomy in skull-base surgery. TAToo directly predicts the motion from surgical videos, without the need of any markers. Our results show that the performance of TAToo compares favorably to competing approaches. Future work will include fine-tuning of our depth network to reach a 1 mm clinical accuracy goal desired for surgical applications in the skull base.

As the number of distributed services (or microservices) of cloud-native applications grows, resource management becomes a challenging task. These applications tend to be user-facing and latency-sensitive, and our goal is to continuously minimize the amount of CPU resources allocated while still satisfying the application latency SLO. Although previous efforts have proposed simple heuristics and sophisticated ML-based techniques, we believe that a practical resource manager should accurately scale CPU resources for diverse applications, with minimum human efforts and operation overheads. To this end, we ask: can we systematically break resource management down to subproblems solvable by practical policies? Based on the notion of CPU-throttle-based performance target, we decouple the mechanisms of SLO feedback and resource control, and implement a two-level framework -- Autothrottle. It combines a lightweight learned controller at the global level, and agile per-microservice controllers at the local level. We evaluate Autothrottle on three microservice applications, with both short-term and 21-day production workload traces. Empirical results show Autothrottle's superior CPU core savings up to 26.21% over the best-performing baselines across applications, while maintaining the latency SLO.

Generalisation to unseen contexts remains a challenge for embodied navigation agents. In the context of semantic audio-visual navigation (SAVi) tasks, the notion of generalisation should include both generalising to unseen indoor visual scenes as well as generalising to unheard sounding objects. However, previous SAVi task definitions do not include evaluation conditions on truly novel sounding objects, resorting instead to evaluating agents on unheard sound clips of known objects; meanwhile, previous SAVi methods do not include explicit mechanisms for incorporating domain knowledge about object and region semantics. These weaknesses limit the development and assessment of models' abilities to generalise their learned experience. In this work, we introduce the use of knowledge-driven scene priors in the semantic audio-visual embodied navigation task: we combine semantic information from our novel knowledge graph that encodes object-region relations, spatial knowledge from dual Graph Encoder Networks, and background knowledge from a series of pre-training tasks -- all within a reinforcement learning framework for audio-visual navigation. We also define a new audio-visual navigation sub-task, where agents are evaluated on novel sounding objects, as opposed to unheard clips of known objects. We show improvements over strong baselines in generalisation to unseen regions and novel sounding objects, within the Habitat-Matterport3D simulation environment, under the SoundSpaces task.

Prior work has shown that coupling sequential latent variable models with semantic ontological knowledge can improve the representational capabilities of event modeling approaches. In this work, we present a novel, doubly hierarchical, semi-supervised event modeling framework that provides structural hierarchy while also accounting for ontological hierarchy. Our approach consists of multiple layers of structured latent variables, where each successive layer compresses and abstracts the previous layers. We guide this compression through the injection of structured ontological knowledge that is defined at the type level of events: importantly, our model allows for partial injection of semantic knowledge and it does not depend on observing instances at any particular level of the semantic ontology. Across two different datasets and four different evaluation metrics, we demonstrate that our approach is able to out-perform the previous state-of-the-art approaches, demonstrating the benefits of structured and semantic hierarchical knowledge for event modeling.

As language models (LMs) scale, they develop many novel behaviors, good and bad, exacerbating the need to evaluate how they behave. Prior work creates evaluations with crowdwork (which is time-consuming and expensive) or existing data sources (which are not always available). Here, we automatically generate evaluations with LMs. We explore approaches with varying amounts of human effort, from instructing LMs to write yes/no questions to making complex Winogender schemas with multiple stages of LM-based generation and filtering. Crowdworkers rate the examples as highly relevant and agree with 90-100% of labels, sometimes more so than corresponding human-written datasets. We generate 154 datasets and discover new cases of inverse scaling where LMs get worse with size. Larger LMs repeat back a dialog user's preferred answer ("sycophancy") and express greater desire to pursue concerning goals like resource acquisition and goal preservation. We also find some of the first examples of inverse scaling in RL from Human Feedback (RLHF), where more RLHF makes LMs worse. For example, RLHF makes LMs express stronger political views (on gun rights and immigration) and a greater desire to avoid shut down. Overall, LM-written evaluations are high-quality and let us quickly discover many novel LM behaviors.

The feasibility of collecting a large amount of expert demonstrations has inspired growing research interests in learning-to-drive settings, where models learn by imitating the driving behaviour from experts. However, exclusively relying on imitation can limit agents' generalisability to novel scenarios that are outside the support of the training data. In this paper, we address this challenge by factorising the driving task, based on the intuition that modular architectures are more generalisable and more robust to changes in the environment compared to monolithic, end-to-end frameworks. Specifically, we draw inspiration from the trajectory forecasting community and reformulate the learning-to-drive task as obstacle-aware perception and grounding, distribution-aware goal prediction, and model-based planning. Firstly, we train the obstacle-aware perception module to extract salient representation of the visual context. Then, we learn a multi-modal goal distribution by performing conditional density-estimation using normalising flow. Finally, we ground candidate trajectory predictions road geometry, and plan the actions based on on vehicle dynamics. Under the CARLA simulator, we report state-of-the-art results on the CARNOVEL benchmark.

As AI systems become more capable, we would like to enlist their help to supervise other AIs. We experiment with methods for training a harmless AI assistant through self-improvement, without any human labels identifying harmful outputs. The only human oversight is provided through a list of rules or principles, and so we refer to the method as 'Constitutional AI'. The process involves both a supervised learning and a reinforcement learning phase. In the supervised phase we sample from an initial model, then generate self-critiques and revisions, and then finetune the original model on revised responses. In the RL phase, we sample from the finetuned model, use a model to evaluate which of the two samples is better, and then train a preference model from this dataset of AI preferences. We then train with RL using the preference model as the reward signal, i.e. we use 'RL from AI Feedback' (RLAIF). As a result we are able to train a harmless but non-evasive AI assistant that engages with harmful queries by explaining its objections to them. Both the SL and RL methods can leverage chain-of-thought style reasoning to improve the human-judged performance and transparency of AI decision making. These methods make it possible to control AI behavior more precisely and with far fewer human labels.